By

(0 Reviews)

Edited by the world leaders in this emerging field, this three-volume handbook is designed to become the landmark reference on this exciting new branch of chemistry and biology. Following an introductory section, the authors discuss the use of small molecules to explore biology, discovering small molecule probes for biological mechanisms and expanding the scope of chemical synthesis. Further sections cover chemical informatics, drug discovery and systems biology, and the whole work is rounded off by the outlook and perspectives for this field. No academic institution or pharmaceutical company can possibly miss out on this highly authoritative work....more

By Edward Kerns, Li Di,

4.5 (5 Reviews)

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a pra...more

By Robert A. Copeland,

5.0 (3 Reviews)

Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are pres...more

By Donal O'Shea,

4.0 (26 Reviews)

“O'Shea tells the fascinating story of this mathematical mystery and its solution by the eccentric Mr. Perelman.”—Wall Street Journal In 1904, Henri Poincaré, a giant among mathematicians who transformed the fledging area of topology into a powerful field essential to all mathematics and physics, posed the Poincaré conjecture, a tantalizing puzzle that speaks to the possible shape of the universe. For more than a century, the conjecture resisted attempts to prove or disprove it. As Donal O’Shea reveals in his elegant narrative, Poincaré’s conjecture opens a door to the history of geometry, from the Pythagoreans of ancient Greece to the celebrated geniuses of the nineteenth-century German academy and, ultimately, to a fascinating array of personalities—Poincaré and Bernhard ...more

By Leon Lederman, Dick Teresi,

4.5 (55 Reviews)

In this extraordinarily accessible and enormously witty book, the Nobel Prize-winning physicist Leon Lederman guides us on a fascinating tour of the history of particle physics. The book takes us from the Greeks' earliest scientific observations through Einstein and beyond in an inspiring celebration of human curiosity. It ends with the quest for the Higgs boson, nicknamed the God Particle, which scientists hypothesize will help unlock the last secrets of the subatomic universe. With a new preface by Lederman, The God Particle will leave you marveling at our continuing pursuit of the infinitesimal....more

By Michio Kaku,

4.5 (17 Reviews)

In paperback for the centenary of the discovery of relativity, "a fresh and highly visual tour through Einstein's astonishing legacy" (Brian Greene). The year 2005 marks the 100th anniversary of the publication of the paper that launched Einstein's career, made E=mc2 famous, and ushered in a revolution in science—the paper that announced the theory of special relativity. And there's no better short book that explains just what Einstein did than Einstein's Cosmos. Keying Einstein's crucial discoveries to the simple mental images that inspired them, Michio Kaku finds a revealing new way to discuss these ideas, and delivers an appealing and always accessible introduction to Einstein's work....more

By Michael Belfiore,

4.5 (20 Reviews)

On June 21, 2004, SpaceShipOne, built by aircraft designer Burt Rutan, entered space and ushered in the commercial space age. Investment capital began to pour into the new commercial spaceflight industry. Richard Branson's VirginGalactic will begin ferrying space tourists out of the atmosphere in 2010. Las Vegas hotelier Robert Bigelow is developing the world's first commercial space station (i.e., space hotel). These space entrepreneurs, including Microsoft cofounder Paul Allen and Amazon.com founder Jeff Bezos, now see space as the next big thing. In Rocketeers, Michael Belfiore goes behind the scenes of this nascent industry, capturing its wild-west, anything-goes flavor. Likening his research to "hanging out in the Wright brothers' barn," Belfiore offers an inspiring and entertainin...more